366. Anesthetic loss to the plastic and rubber components of the anesthetic circuit hindering achievement of an adequate inspired concentration is a factor with which of the following anesthetics?

 A. Desflurane B. Nitrous oxide C. Sevoflurane D. Isoflurane E. All of the above

(D) Anesthetic agents are soluble in the rubber and plastic components found in the anesthesia machine. This fact

can impede the development of anesthetic concentrations of these drugs. The worst offender is the obsolete

volatile methoxyflurane. However, both isoflurane and halothane are soluble in rubber and plastic, but to a lesser

degree. Sevoflurane, desflurane, and nitrous oxide have little or no solubility in rubber or plastic. A different but

important issue should be borne in mind regarding loss of sevoflurane. This agent can be destroyed in appreciable

quantities by Baralyme and soda lime, but not calcium hydroxide lime (Amsorb). It is therefore recommended

that fresh-gas flow rates exceed 2 L/min when sevoflurane is administered